Cyclin D1 Expression and Patient Outcome after Tamoxifen Therapy in Estrogen Receptor Positive Brest Cancer
نویسندگان
چکیده
منابع مشابه
Cyclin D1 expression in breast cancer patients receiving adjuvant tamoxifen-based therapy.
PURPOSE The objective of our study was to determine the clinical relevance of cyclin D1 expression in hormone receptor-positive breast cancer patients who were treated with tamoxifen-based therapy. EXPERIMENTAL DESIGN We assessed expression of cyclin D1 in surgical specimens of breast carcinoma by means of immunohistochemistry. Patients had been enrolled in either Austrian Breast and Colorect...
متن کاملOverexpression of cyclin D1 messenger RNA predicts for poor prognosis in estrogen receptor-positive breast cancer.
Cyclin D1 is a key cell cycle regulatory protein with demonstrated oncogenic activity in a variety of malignancies. Cyclin D1 mRNA and protein are overexpressed in approximately 50% of primary breast carcinomas; however, the pathophysiological consequences of increased expression remain unclear. To investigate the functional sequelae of cyclin D1 mRNA overexpression, we analyzed clinical outcom...
متن کاملFunctional activity of ectopically expressed estrogen receptor is not sufficient for estrogen-mediated cyclin D1 expression.
Estrogen receptor function can drive cyclin D1 expression and proliferation in human breast cancer cells (MCF-7). Recent studies showing that estrogen receptor-positive epithelial cells in the human mammary gland are nonproliferative suggest that the direct mitogenic effect of estrogen on mammary epithelial cells may be acquired during breast cancer development. Because estrogen-dependent cycli...
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Cyclin D1, a cell cycle regulator essential for G1 phase progression, has been implicated in the pathogenesis of certain cancers. High levels of these proteins have been reported in certain human malignancies and have been implicated in aberrant cell division and dysregulated tumor growth. In this study, 30 prostate cancer and 25 benign prostate tissues were studied for cyclin D1 expression usi...
متن کاملCyclin D1 Expression in Patients with Laryngeal Squamous Cell Carcinoma
Background & Objective: Laryngeal squamous cell carcinoma (LSCC) is considered to be one of the most common cancers of the head and neck, accounting for roughly 90% of all malignant tumors of the larynx. To have a timely diagnosis for a better and practical therapy, molecular markers have to be investigated. The aim of this study was to determine the expression of Cyclin D1 (CD...
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ژورنال
عنوان ژورنال: Journal of Korean Breast Cancer Society
سال: 1999
ISSN: 1598-3641
DOI: 10.4048/jkbcs.1999.2.2.221